Annona muricata L., Stem-Bark Exhibit Antidepressant-Like Activity in SpragueDawley Rats

Annona muricata L. (Annonaceae) is widely used in the Amazon and Carribean natural medicine as an antiparasitic, insecticidal, sedative astringent for diarrhea among others. In Nigeria however, under-utilized species of plants. This study investigated antidepressant ambulatory effect A. muricata, using open field test forced swim tests on Sprague-Dawley rats administered ethanol stem-bark extracts Nigerian grown species. Rats were extract (50, 150 300mg/kg) alone combination with drugs imipramine sertraline (10mg/kg), respectively 14 days. The administration was observed to cause a significant reduction swimming time immobility test. behavior decrease when (150 while much further explorative tendencies combined sertraline. results suggested that A.muricata, possess effects.